Lake Of The Ozarks |  stargazzerCreighton, NE67, joined Feb. 2007You dipsy-doodle ~~ you certainly don't know much about good farming dogs The dalmation is one of the earliest farming dogs there was --- they are wonderful with horses. Dalmation are nasty dogs, takes a fire house to train one. cupocheerAssumption, IL67, joined May. 2010Dalmation are nasty dogs, takes a fire house to train one. woodsmammaBabbitt, MN63, joined Feb. 2009cool story. I don't live on a farm yet. Out here neighbors bought Akitas to keep bears away. I was hoping someone would say lab. I had a Border Collie that was decapitated and skinned. When I reported it to Sheriff's Dept. they said it was ritualistic. That is about the most tragic thing I have ever heard about cruelty to animals. Swearing about it won't help I guess, but dang!!!stargazzerCreighton, NE67, joined Feb. 2007The old b*tch above me is not my choice 417 posts, read 688,111 times "Many herding dog breeds are afflicted with a mutation of the multi-drug resistance (mdr1) gene.

This gene encodes a protein (P-glycoprotein) that is responsible for removing certain drugs and toxins from the brain. Dogs that carry the mdr1 genetic defect cannot rid their brains of the problem drugs. The result is a neurotoxic buildup that can cause abnormal neurological symptoms and/or death." 1,056 posts, read 3,392,679 times I've never heard of it but this is what I found. Drugs reported to cause problems in dogs that carry the MDR1 mutation. Information from the VCPL at Washington State University. 1,203 posts, read 2,966,359 times Originally Posted by jaime_macTHAT is a relief ... i had not heard of this .... bailey (red heeler mix) has been on heartguard for most of her 5-1/2 years......... 3,419 posts, read 10,290,585 times No issue for mine since both have had ivermectin for much of their 7 and 8 years but even GSDs can have it - I thought it was strictly collies. I will have to keep that in mind next time around. Breeds of dogs affected with the mutant MDR1 gene.

Originally Posted by latetotheparty Heartguard has such a low dose that it doesn't affect them, but the dose that Buster had to take for the mange treatment was WAY high and they couldn't even have heartworm meds while he was on it, and Bella wasn't even taking it!Boykin Puppies For Sale Sc 3,965 posts, read 7,335,736 timesMid Century Modern Homes For Sale Norwalk Ct Jazz, Dash both part border collie and Phoenix Aussie none were ever tested but my vet has always been careful of any medicines they have had. Sell Broken Laptop CorkHe mentioned it being a common issue with collie type dogs. I think it causes a neurotoxicity when they get the drugs like ivermectin. MDR1 is a multidrug resistance so other drugs could cause problems too